Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Introduction.- Basic rules of T cell migration.- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging.- Vascular normalization, T cell trafficking and anti-tumor immunity.- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts.- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic.- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy.- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors.- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.

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• Imunologia
• Pesquisa médica
• Oncologia

Cancer Treatment;Anti-tumor immune response;Immogenic tumors;Cancer-associated fibroblasts;Cancer-associated Tertiary Lymphoid Structures;Cancer immunotherapy;Chemokines;Chimeric antigen receptor