Fundamentals of Neurodegeneration and Protein Misfolding Disorders

Introduction.- Protein Folding, Part I: Basic Principles.- Protein Folding, Part II: Energy Landscapes and Protein Dynamics.- Protein Misfolding and Aggregation.- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System.- Protein Quality Control, Part II: Autophagy and Aging.- Prion Diseases.- Alzheimer's Disease.- Parkinson's Disease.- Huntington's Disease and other Unstable Repeat Disorders.- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.

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• Química orgânica
• Neurologia e neurofisiologia clínica
• Neurociências
• Biofísica
• Engenharia biomédica
• Bioquímica
• Proteinas

Abeta, Tau;Alpha-synuclein;Alpha-synucleinopathies;Alzheimer's Disease;Amyloid Fibrils;Amyloid Oligomers;Amyloids;Amyotrophic Lateral Sclerosis;Huntington's Disease;Intracellular Inclusions;Neurodegeneration;Parkinson's Disease;Prions;Protein Misfolding;TDP-43;TDP-43 Proteinopathies;Tauopathies;Unstructured Proteins