Handbook of Complexity in Medicine

Introduction to complexity.- The mathematics of complexity.- Philosophy of complexity.- Prediction and decision making.- Information, noise... and meaning?.- "Systems" and complexity.- Small scale. Of a unifying theory in medicine.- Quantum physics and biology.- The "dark side" of our genomes: spatial organization, noise, etc.- Organization, balance between noise and information.- Networks theory and the inner life of cells.- Form and function, old paradigm true again?.- The missing mesoscales.- The magnitude of a human. What you do with what you got: of genes and the environment.- The virtual human.- The disaster of disease. A failing human.- A human ecosystem. Of identity and complexity.- Being so meta. Humans, between freedom and determinism.- Defining a human: what we eat, do, think.- Competing cultures and the righteous mind.- Stigma. Making sense as a cure and a disease.- The struggle for enlightenment. Section A The human brain 20 Cells, areas, networks, etc.- Tooling up for brain research.- Modeling the brain. Blowing a ghost in the shell.- Building, toying, and understanding.- Informing mental health. The DSM and beyond.- At the heart of a human.- Physiome project.- Multiple models of a single organ. Can we put Humpty Dumpty back together?.- Medicine and basic sciences. More than the sum of the parts.- Heart-brain connection.- A map of metabolism.- ReconX and the gps of metabolism.- Translating the models into practice.- The gaps in the map.- Clinical AI 32 Profiling and other strategies.- Infectious diseases.- Cancer therapy.- The hackers' philosophy in medical research.- Lost and found in translation.- From biological insights to clinical intelligence.- Of models and clinical pathways.- Generalizing average Joe.- Bigdata and medicine.- The resistance to adoption.- Medicine Vs Research?.- The beauty of small.- Power of one.- Tools for uncertainty.- Extending the model.- Data. Collection, quality, analyses.- eHealth as the trait d'union between research and medicine.- Clinical models. Competition and emulation between doctors and AI. The clinical dilemma.- Time as a partner. Ticking beyond rhethorics.- Care as a negotiation of values.- The burden of care and Ulysses' syndrome. Complexity in practice.- Healthcare as an ecosystem. Is every change possible?.- Narratives of disease, false memories and prejudice. 1+1+...= public health?.- Personalized medicine and public health.- Rethinking failure and success.- Care cycle as education.- The people in the room. Who cares?.- Time as the enemy. Disaster and crisis management.- The economics of health.- Health between commons and commodity.- Patient at the centre. Client or partner.- Design for sustainable Health.- Is antifragility possible for healthcare?.- Preparing for the worse.- The laws of medicine.- Lives lost and saved. Counting and responsibility.- Agency in care.- My brain made me do that and the law.- Medical Humanities.- Art as a mean to make sense of health and disease.- Narratives to map the unknown.

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• Medicina interna e clínica

Clinical governance;Fundamental research in practice;Medical decision making;Philosophy of medicine;Systems medicine