Lipids in Protein Misfolding

Role of Lipids in Folding, Misfolding and Function of Integral Membrane Proteins.- Protein Misfolding in Lipid-Mimetic Environments.- Lipids in Amyloid-? Processing, Aggregation, and Toxicity.- Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis.- Stability, Oligomerization, and Amyloidogenicity of Apo Serum Amyloid A.- Interactions of Lipid Membranes with Fibrillar Protein Aggregates.- The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II.- Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.- Computational Approaches to Identification of Aggregation Sites and the Mechanism of Amyloid Growth.- Role of Syndecans in Lipid Metabolism and Human Diseases.

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• Proteinas
• Bioquímica
• Pesquisa médica
• Química orgânica

amyloid formation;biophysical and structural approaches;molecular mechanisms of protein misfolding;protein misfolding in amyloid diseases;protein-lipid interactions;Protein Structure