Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Hirakawa, Akihiro; Sato, Hiroyuki; Daimon, Takashi; Matsui, Shigeyuki

Springer Verlag, Japan

02/2018

89

Mole

Inglês

9784431555728

15 a 20 dias

454

Descrição não disponível.

1. Introduction.- 2. Phase I Trials for Drug Development in Oncology.- 3. A Summary of Dose.- Finding Methods in Standard Phase I Trials .- 4. Phase I Trials for Combination of Two Agents.- 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity.- 6. Additional Topics on Adaptive Dose.- Finding Methods.

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Adaptive Design;Cancer;Dose Finding;Phase I;Phase I/II