Radiobiology of Glioblastoma
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Radiobiology of Glioblastoma
Recent Advances and Related Pathobiology
Giordano, Antonio; Pirtoli, Luigi; Gravina, Giovanni Luca
Birkhauser Verlag AG
05/2018
305
Mole
Inglês
9783319803210
15 a 20 dias
6918
Descrição não disponível.
Introduction and Background.- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options.- Radiobiological Hints from Clinical Studies.- Chemo-radiotherapy: Radiation Total Dose and Fractionation.- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy.- Mathematical Modeling of Radiobiological Parameters from Clinical Studies.- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series.- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond.- Basic Knowledge of Glioblastoma Radiobiology.- Molecular Radiobiology and Mathematical Modeling.- Genetic and Epigenetic Determinants in Tumor Initiation and Progression.- Tumor Microenvironment.- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy.- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models.- Glioma Stem-like Cells and Radiation Resistance.- Hypoxia and Radiation Resistance.- Invasiveness and Radiation Failures.- Nanoparticle Technology for Research Radiobiology.- The Molecular Classification of Glioblastoma as a Translational Instrument.- Translational Perspectives for Gene Therapy.- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods.- From Molecular to Clinical Radiation Biology.- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results.- Conclusive Remarks and Perspectives for Future Research.
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Particle Radiation Therapy;Radiobiological Parameters;Tumor Initiation;Tumor Microenvironment;Gene Therapy
Introduction and Background.- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options.- Radiobiological Hints from Clinical Studies.- Chemo-radiotherapy: Radiation Total Dose and Fractionation.- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy.- Mathematical Modeling of Radiobiological Parameters from Clinical Studies.- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series.- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond.- Basic Knowledge of Glioblastoma Radiobiology.- Molecular Radiobiology and Mathematical Modeling.- Genetic and Epigenetic Determinants in Tumor Initiation and Progression.- Tumor Microenvironment.- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy.- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models.- Glioma Stem-like Cells and Radiation Resistance.- Hypoxia and Radiation Resistance.- Invasiveness and Radiation Failures.- Nanoparticle Technology for Research Radiobiology.- The Molecular Classification of Glioblastoma as a Translational Instrument.- Translational Perspectives for Gene Therapy.- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods.- From Molecular to Clinical Radiation Biology.- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results.- Conclusive Remarks and Perspectives for Future Research.
