Store-Operated Ca (2)? Entry (SOCE) Pathways
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Store-Operated Ca (2)? Entry (SOCE) Pathways
Emerging Signaling Concepts in Human (Patho)physiology
Graier, Wolfgang F.; Romanin, Christoph; Groschner, Klaus
Springer International Publishing AG
09/2017
645
Dura
Inglês
9783319577319
15 a 20 dias
Descrição não disponível.
Part 1. SOCE - Fundamental Mechanistic Concepts.- 1. Introduction.- 2. STIM/Orai Structures: Isolated and in Complex.- 3. Orai, the Pore-Forming Subunit of the CRAC Channel.- 4. The Interactions between STIM and Orai.- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry.- 6. Regulation of STIM and Orai by Thiol Modifications.- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels.- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes.- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function.- 10. Auxiliary Proteins of the STIM/Orai Complex.- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments.- 11. Introduction.- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE.- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores.- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+Entry and Mitochondria.- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry.- 16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry.- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling.- 18. Tissue specificity SOCE - Implications for Ca2+ Handling in Endothelial Cells.- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes.- Part 3. SOCE - Molecular and Cellular (Patho) Physiology.- 20. Introduction.- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes.- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders.- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction.- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells - Emerging Targets for Therapeutic Intervention.- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology.- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology.- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function.- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle.- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation.- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease.- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.
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Calcium Signaling;STIM-Orai Pathway;TRP Pathways;Crystal Structure Core Complex;Calcium Entry Pathways
Part 1. SOCE - Fundamental Mechanistic Concepts.- 1. Introduction.- 2. STIM/Orai Structures: Isolated and in Complex.- 3. Orai, the Pore-Forming Subunit of the CRAC Channel.- 4. The Interactions between STIM and Orai.- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry.- 6. Regulation of STIM and Orai by Thiol Modifications.- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels.- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes.- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function.- 10. Auxiliary Proteins of the STIM/Orai Complex.- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments.- 11. Introduction.- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE.- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores.- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+Entry and Mitochondria.- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry.- 16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry.- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling.- 18. Tissue specificity SOCE - Implications for Ca2+ Handling in Endothelial Cells.- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes.- Part 3. SOCE - Molecular and Cellular (Patho) Physiology.- 20. Introduction.- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes.- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders.- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction.- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells - Emerging Targets for Therapeutic Intervention.- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology.- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology.- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function.- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle.- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation.- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease.- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.
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