Role of Microenvironment in the Control of Tumor Angiogenesis

Prelims

1. Tumor microenvironment

1.1. Metastatic
cascade

1.2.
Epithelial-mesenchymal transition

1.3. The
extracellular matrix

2. Tumor blood
vessels and tumor endothelial cells




2.1. Tumor
basement membrane

2.2. Tumor
pericytes3. Tumor
angiogenesis



3.1. Sprouting
angiogenesis

3.2. Vascular
co-option

3.3.
Vasculogenic mimicry

3.4.
Intussusceptive microvascular growth



4. Inflammatory
cells in tumor microenvironment

4.1.
Neutrophils4.2.
Eosinophils and dendritic cells

4.3.
Lymphocytes and platelets

4.4. Mast cells

4.5. Macrophages

4.6. Tie-2
expressing monocytes (TEMs)

4.7. Fibroblasts

4.8. Osteoblasts and osteoclasts

4.9. Cancer
stem cells (CSCs)4.10.Circulating
endothelial cells and endothelial precursor cells

4.11. Multipotents adult progenitor cells (MAPCs) and myeloid-derived suppressor
cells (MDSCs)

5. Therapeutic
strategies, the concept of "normalization" and the role of VEGF inhibition




Index

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• Oncologia
• Farmacologia
• Oncologia
• Patologia

angiogenesis;anti-angiogenesis;tumor growth;tumor microenvironment;tumor progression;pharmacotherapy