Non-coding RNAs in Colorectal Cancer

Introduction.-Part I Non-coding RNAs: biology and implications in colorectal cancer pathogenesis.-Non-coding RNAs: classification, biology and functioning.-Involvement of non-coding RNAs in hallmarks and key signaling pathways of colorectal cancer.-MicroRNAs and inflammation in colorectal cancer.- Interplay between transcription factors and microRNAs regulating epithelial-mesenchymal transitions in colorectal cancer.- Non-coding RNAs functioning in colorectal cancer stem cells.- MicroRNA Methylation in Colorectal Cancer.- Polymorphisms in non-coding RNA genes and their targets sites as risk factors of sporadic colorectal cancer.- Part II Non-coding RNAs: new class of biomarkers in colorectal cancer.- Non-coding RNAs as biomarkers for colorectal cancer screening and early detection.- Circulating non-coding RNAs as biomarkers in colorectal cancer.- Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients.- Part III Non-coding RNAs: therapeutic targets and colorectal cancer therapeutics.- Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer.- Non-coding RNAs: therapeutic strategies and delivery systems.- MicroRNAs as therapeutic targets and colorectal cancer therapeutics.- Summary.- Index.

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• Ciências da vida: temas gerais
• Oncologia
• Biologia Celular (citologia)
• Genética médica
• Pesquisa médica

Non-coding RNAs;biomarkers;colorectal cancer;long non-coding RNAs;microRNAs;pathogenesis;therapy