Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Yoshimura, Akihiko

Springer International Publishing AG

09/2018

267

Mole

Inglês

9783319886848

15 a 20 dias

454

Descrição não disponível.
Regulatory T cells: molecular and cellular basis for immunoregulation.- Overview of LAG-3- expressing, IL-10-producing regulatory T cells.- Regulatory Dendritic Cells.- Role of PD-1 in immunity and diseases.- CTLA-4, an essential immune-checkpoint for T cell activation.- Tim-3, Lag-3, and TIGIT.- SOCS1: regulator of T cells in autoimmunity and cancer.- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity.- Immune regulation by ubiquitin tagging as checkpoint code.- MicroRNA in Immune Regulation.
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Anti-tumor immune response;Tumor immune microenvironment;Regulatory T cells;PD-1;Autoimmune disease;Immunoregulation;Cancer therapy;Regulatory dendritic cells;Extracellular immune checkpoint molecules;Intracellular immune checkpoint molecules;CTLA-4;Tim-3;Lag-3;TIGIT;SOCS1;Tregs