RNA/DNA and Cancer
-15%
portes grátis
RNA/DNA and Cancer
Sinkovics, Joseph G.
Springer International Publishing AG
04/2016
815
Dura
Inglês
9783319222783
15 a 20 dias
Descrição não disponível.
Preface. Introductions. I THE PRIMORDIAL RNA/DNA COMPLEX EVOLVING.- The Primordial Genes Are Conserved as Stem Cell Genes and Proto-Oncogenes.- The First Cells Ascend.- Eukaryotic Single Cells and the First Cell Communities Then and Now.- A Highly Effective Immune System Predating Adaptive Immunity.- Elements of Adaptive Immunity Self-Assemble.- The RNA/DNA Complex at Work.- YY Proteins.- Elusive Alleles.- The Long Trajectory of the IGF-like Receptor and Its Ligands.- Primordial Fused Genes Become Oncogenes and Encode Oncoproteins.- Performance in the Laboratory.- Inbuilt Errors not yet Corrected.- Errors or Inherent Attributes for the Sustenance of Unicellular Life.- Viral Genomic Insertions into the Host Cell's Genome.- Viral and Cellular Proteins Interact.- Light Cast to Broken DNA, Its Repair, and Consequences.- Undisciplined Introns.- Elementary Epigenomics.- RNA/DNA: Bioengineers Supreme.- II THE ONCOGENOME.- Seamless Unity of the Nucleus and Cytoplasm: the Membranes Are Permeable.- Endogenously Initiated Immortalization is Welcome. Enforced Carcinogenesis by Exogenous Alien Initiator Is Resisted.- A Condensed Compendium.- "Malignant Transformation".- III THE HUMAN CEREBRAL CORTICAL DNA AGAINST CANCER CELL DNA.- Will the Human Cerebral Cortex Subdue the Oncogenome?- In Self-Defense, the Cancer Cell Reactivates Its Primordial Genome Loaded with Proviruses in Order to Mobilize All Its Remaining Survival Pathways.- The Cancer Cell Viewed as a Unicellular Parasite (an Amoeba).- Astute Observers Withstand Derision.- "Making Cancer History" at M.D. Anderson Hospital.- SUMMARY.- Appendix 1.-Appendix 2.- Index.
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ancient eukaryotic cell survival pathways;cancer immunology/immunotherapy;cancer virology;oncolytic viruses;proto-oncogenes/oncogenes
Preface. Introductions. I THE PRIMORDIAL RNA/DNA COMPLEX EVOLVING.- The Primordial Genes Are Conserved as Stem Cell Genes and Proto-Oncogenes.- The First Cells Ascend.- Eukaryotic Single Cells and the First Cell Communities Then and Now.- A Highly Effective Immune System Predating Adaptive Immunity.- Elements of Adaptive Immunity Self-Assemble.- The RNA/DNA Complex at Work.- YY Proteins.- Elusive Alleles.- The Long Trajectory of the IGF-like Receptor and Its Ligands.- Primordial Fused Genes Become Oncogenes and Encode Oncoproteins.- Performance in the Laboratory.- Inbuilt Errors not yet Corrected.- Errors or Inherent Attributes for the Sustenance of Unicellular Life.- Viral Genomic Insertions into the Host Cell's Genome.- Viral and Cellular Proteins Interact.- Light Cast to Broken DNA, Its Repair, and Consequences.- Undisciplined Introns.- Elementary Epigenomics.- RNA/DNA: Bioengineers Supreme.- II THE ONCOGENOME.- Seamless Unity of the Nucleus and Cytoplasm: the Membranes Are Permeable.- Endogenously Initiated Immortalization is Welcome. Enforced Carcinogenesis by Exogenous Alien Initiator Is Resisted.- A Condensed Compendium.- "Malignant Transformation".- III THE HUMAN CEREBRAL CORTICAL DNA AGAINST CANCER CELL DNA.- Will the Human Cerebral Cortex Subdue the Oncogenome?- In Self-Defense, the Cancer Cell Reactivates Its Primordial Genome Loaded with Proviruses in Order to Mobilize All Its Remaining Survival Pathways.- The Cancer Cell Viewed as a Unicellular Parasite (an Amoeba).- Astute Observers Withstand Derision.- "Making Cancer History" at M.D. Anderson Hospital.- SUMMARY.- Appendix 1.-Appendix 2.- Index.
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